According to research, around 40 million men in the US experience erectile dysfunction (ED) at some point in their life. If you’re one of them, it would be reassuring to know that many treatments and medications are now available to treat the condition.

One such group of medication that’s widely used is phosphodiesterase type 5 inhibitors. PDE5 inhibitors can help improve a person’s sexual desire and erection.

Let’s look at some of the most commonly used PDE5 inhibitors.

Sildenafil (Viagra)

This was the first well-researched PDE5 inhibitor that the FDA later approved in the late 1990s. Its market name is Viagra, and it takes effect within a single hour of consumption.

Sildenafil’s effects may last from 4 to 12 hours, depending on the dose. Common side effects of Viagra include:

• Flushing
• Nasal congestion
• Vision problems
• Headaches
• Nasal congestion
• Cold-like symptoms

Tadalafil (Cialis)

This medication was introduced in the early 2000s. Compared to Viagra, Tadalafil takes effect within 15-20 minutes and should be consumed at least 30 minutes before sex. It has also been approved by FDA.

Its effect may last from 24 to 36 hours. Common side effects of Taladafil include:

• Muscle pain
• Back pain
• Cold-like symptoms
• Flushing
• Indigestion
• Headache
• Nasal congestion

Vardenafil (Staxyn or Levitra)

Vardenafil was also approved during the early 2000s as a treatment for ED. Among all the inhibitors, it has the shortest onset time and takes effect in less than 10 minutes.

Its effect may last anywhere from 5 to 7 hours, and its side effects include:

• Vision problems
• Cold-like symptoms
• Nasal congestion
• Headaches
• Flushing
• Indigestion

Avanafil (Stendra)

This medication’s effect lasts longer than sildenafil and vardenafil but less than tadalafil. Avanafil’s dosage is usually between 50-200 mg per day. Common side effects of consuming avanafil include:

• Flushing
• Headache
• Indigestion
• Cold-like symptoms
• Nasal congestion

What are the other sources of PDE5 inhibitors?

While you can buy the mentioned medications to treat erectile dysfunction, some natural food sources can have the same effect. PDE5 is found in some natural herbs that are sold as supplements.

These herbs include:

• Epimedium
• Black ginger (Kaempferia parviflora)
• Malculra pomifera

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